교수

본 연구실은 해양생물에 공생하는 호기성 및 혐기성 미생물을 분리 배양한 다음, 로봇을 이용하는 대량검색법을 통해 생리활성천연물의 화학구조를 규명한다. 개발된 천연물의 AI-빅데이터 기반 분자모델링을 통해 선도물질을 도출하고 최적화하며 약물적합성과 약물동력학적 평가를 거쳐 질환동물모델에서 그 효능을 평가한 다음, 기초독성 평가를 통해 신약후보물질을 개발하고 있다. 대상질환은 비만, 당뇨, 죽상경화증, 지방간, 골다공증, 감염증 등이고 그 외 지구력 증진 물질을 개발 중이다.

• Ph.D., Marine Natural Products Chemistry, University of California, San Diego, CA, USA, Professor William Fenical, 1994
• M.S., Chemical Instrumentation, Seoul National University, Seoul, Korea, Professor Kyung-Ryul Kim, 1988
• B.S., Oceanography (major) and Chemistry/Biology (minors), Seoul National University, Seoul, Korea, 1986

• Member, Presidential Council for Future & Vision, Korea, 2010-2013
• Director, The Center for Marine Natural Product & Drug Discovery, Ministry of Oceans & Fisheries, Seoul, Korea, 2004-2013
• Professor, School of Earth & Environmental Sciences and Interdisciplinary Graduate Program in Genetic Engineering, Seoul National University, Seoul, Korea, 1998-
• Research Associate, The Salk Institute/Howard Hughes Medical Institute, La Jolla, CA, USA, 1994-1998

1. Yong-Xu Wang, Chih-Hao Lee, Sambath Tiep, Ruth, T Yu, Jungyeob Ham, Heonjoong Kang, and Ronald M. Evans, (2003). Peroxisome-proliferator-activated receptorδ activates fat metabolism to prevent obesity. Cell, 113(2), 159-170, doi: 10.1016/S0092-8674(03)00269-1
2. Hiyoung Kim, Jungwook Chin, Hyukjae Choi, Kyungryul Baek, Tae-Gu Lee, Seong Eon Park, Weihong Wang, Dongyup Hahn, Inho Yang, Jihye Lee, Bora Mun, Merrick Ekins, Sang-Jip Nam, and Heonjoong Kang, (2013). Phosphoiodyns A and B, Unique Phosphorus-Containing Iodinated Polyacetylenes from a Korean Sponge Placospongia sp. Organic Letters, 15(1), 100-103, doi: 10.1021/ol3031318
3. Jungyeob Ham, Hoosang Hwang, Euno Kim, Jeong-ah Kim, Sung Jin Cho, Jaeyoung Ko, Woojin Lee, Jaehwan Lee, Harish Holla, Joydeep Banerjee, Seokho Kim, Inho Yang, Hyun Joo Lee, Kyoungjin Shin, Hyukjae Choi, Sang-Jip Nam, Jungae Tak, Dongyup Hahn, Taekyung Oh, Dong Hwan Won, Tae Gu Lee, Jihye Choi, Mi Sun Park, Chaok Seok, Jungwook Chin, and Heonjoong Kang, (2012). Discovery, design and synthesis of Y-shaped peroxisome proliferator-activated receptor δ agonists as potent anti-obesity agents in vivo. European Journal of Medicinal Chemistry, 53(July), 190-202, doi: 10.1016/j.ejmech.2012.03.055